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We observed no change in -cell GCGR transcript levels between CFRD and control pancreas, but we cannot rule out that protein levels may be reduced in CFRD

J., Baur, J

4.6 Overcoming challenges in translating natural compounds into clinical applications Despite promising findings, translating the therapeutic potential of natural compounds into clinical practice presents several key challenges

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attributed to histamine H1 receptor activation downstream of mast cell degranulation Pigmentation changes : Darkening of nevi (moles), development of new pigmented lesions, and diffuse skin darkening